The concept of AD as a biological diagnosis based on biomarker positivity has a clear relevance for research, but in most clinical settings, the presence of objective cognitive dysfunction is still representing a “gateway” for a decision about biomarker assessment. Neuropsychological testing plays a central role in the diagnosis of Alzheimer’s disease (AD). The I-UDSNB offers a valuable and harmonized tool for neuropsychological testing in Italy, to be used in clinical and research settings. Higher education and lower age were associated with a better performance in the majority of tests, while sex affected only fluency tests and Digit Span Forward. We collected data from 433 healthy Italian individuals and employed regression models to evaluate the impact of demographic variables on the performance, deriving the reference norms. Methodsįollowing the initiative of the University of Washington’s National Alzheimer’s Coordinating Center (NACC), we presented the Italian adaptation of the Neuropsychological Test Battery of the Uniform Data Set (I-UDSNB). The current study aimed to solve this issue. A major concern is represented by the heterogeneity of the neuropsychological batteries currently adopted in memory clinics and healthcare centers. Neuropsychological testing plays a cardinal role in the diagnosis and monitoring of Alzheimer’s disease. Italian adaptation of the Uniform Data Set Neuropsychological Test Battery (I-UDSNB 1.0): development and normative dataĪlzheimer's Research & Therapy volume 14, Article number: 113 ( 2022)
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